Category: Antibody Discovery

The advent of CRISPR-Cas systems, particularly CRISPR/Cas9, has revolutionized the field of genetic engineering, offering unprecedented precision in editing the genomes of various organisms. This groundbreaking technology has significantly impacted antibody engineering, enabling the generation of custom antibodies and the precise modification of antibody genes. This article explores the role of CRISPR/Cas9 in antibody engineering, …

Yeast surface display has emerged as a powerful and versatile technology for antibody discovery and protein engineering, playing a critical role in therapeutic development. By leveraging the eukaryotic machinery of yeast, this platform ensures proper protein folding and display, enabling the isolation of high-affinity binders through robust library screening. Technology Overview (i) Display Mechanism The …

Protein-protein interactions (PPIs) govern cellular communication and are prime targets for therapeutic intervention. Peptide library screening has emerged as a powerful, high-throughput strategy to dissect these interactions with precision. By systematically displaying thousands of peptide sequences, researchers can map binding epitopes, identify lead compounds, and optimize candidates efficiently. This article outlines the core strategies, technical …