Category: Antibody Discovery

CAR-A for Alzheimer’s: A Breakthrough Neuro-Immunotherapy Using Engineered Astrocytes Introduction Alzheimer’s disease (AD) remains a major challenge, with current anti-Aβ monoclonal antibodies requiring high doses, repeated administration, and carrying risks like ARIA. A pioneering study in Science introduces CAR-A therapy—a next-generation neuro-immunotherapy that engineers astrocytes into super-phagocytes via Chimeric Antigen Receptors. This self-sustaining, one-time intervention …

Yeast surface display has emerged as a powerful and versatile technology for antibody discovery and protein engineering, playing a critical role in therapeutic development. By leveraging the eukaryotic machinery of yeast, this platform ensures proper protein folding and display, enabling the isolation of high-affinity binders through robust library screening. Technology Overview (i) Display Mechanism The …

Protein-protein interactions (PPIs) govern cellular communication and are prime targets for therapeutic intervention. Peptide library screening has emerged as a powerful, high-throughput strategy to dissect these interactions with precision. By systematically displaying thousands of peptide sequences, researchers can map binding epitopes, identify lead compounds, and optimize candidates efficiently. This article outlines the core strategies, technical …